منابع مشابه
DNA Repair: Bacteria Join In
In higher organisms, a major pathway for repairing double stranded breaks in DNA is non-homologous end-joining. Now a similar pathway has been shown to operate in bacterial cells, indicating that this important repair mechanism has been conserved through evolution.
متن کاملDNA Mismatch Repair in Eukaryotes and Bacteria
DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as w...
متن کاملRecombinational DNA Repair in Bacteria: Postreplication
Deoxyribonucleic acid (DNA) damage is a common occurrence in all cells. A bacterial cell growing in an aerobic environment will suffer 3000–5000 DNA lesions per cell per generation (most of them oxidative in origin). Most of this damage is faithfully repaired by specialized DNA repair systems; however, replication forks will occasionally encounter unrepaired DNA lesions. Because DNA polymerase ...
متن کاملSingle-molecule DNA repair in live bacteria.
Cellular DNA damage is reversed by balanced repair pathways that avoid accumulation of toxic intermediates. Despite their importance, the organization of DNA repair pathways and the function of repair enzymes in vivo have remained unclear because of the inability to directly observe individual reactions in living cells. Here, we used photoactivation, localization, and tracking in live Escherich...
متن کاملAncient bacteria show evidence of DNA repair.
Recent claims of cultivable ancient bacteria within sealed environments highlight our limited understanding of the mechanisms behind long-term cell survival. It remains unclear how dormancy, a favored explanation for extended cellular persistence, can cope with spontaneous genomic decay over geological timescales. There has been no direct evidence in ancient microbes for the most likely mechani...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)01385-4